Quintanalab-Calçotada 2019

The Quintanalab-Calçotada 2019 took place on a super sunny April day in El Priorat de Banyeres, a tiny village near Vilafranca. Thanks, Andrea, for offering the house!

It is already a tradition that the whole group gathers together one day to eat calçots with salsa romesco and have fun.

(Please, note Albert’s Salt Bae position…)

Àlex was the calçots chef. A fire was made, and he cooked the calçots with patience and expertise. He did an excellent job as they were very delicious!

After the heavy lunch, to digest, we played dodgeball. Ask Albert who won. Spoiler: not his team.

Then we drunk mojitos and talked and drunk more mojitos… It was a very nice day! Can’t wait for the Quintanalab-Calçotada 2020!

Swiss Light-sheet Microscopy Workshop

Last 24th and 25th of April, Andrea, Pablo, Elisenda and Albert went to Zurich to attend the Swiss Light-sheet Microscopy Workshop.

 

 

It was a two days meeting in which researchers from all over the world gathered together to share the observational techniques they are using. Users and developers discussed newest advances in the field and exchanged ideas.

Elisenda was telling me about these 3D glasses that transported you inside a gigantic transparent brain in which you could observe a specific neuron from all possible angles. Exciting!  Pablo is there in the picture:

 

 

They were very impressed by everything they saw, and learned a lot! Albert said it was a very productive conference and can’t wait to have the chance to try some of these techniques in the lab. He also told me they were happy they had the chance to have a typical Swiss dinner: fondue, raclette and rösti. Fabien might not agree about this being a typical Swiss dinner and not a French one…

We will receive an ERC Proof of Concept Grant!

The European Research Council (ERC) has selected us for a Proof of Concept grant to develop a new research line focused on a novel approach to figh antibiotic resistances: the ResisTEST. This project, derived from the knowledge and experience gathered with NEUROMITO, has been chosen for its innovation potential, its significant impact and its quality, and will receive an amount of 150,000€ for a 18 month period. The objective is to bring closer to the market a new tool to help face one of the most important challenges that society will have to face within the next years: the antibiotic crisis. We are very glad to have this opportunity!

 

Research: Altered protein modifications in mitochondrial disease

Our latest paper is out!

In collaboration with the Frizzell lab at the University of South Carolina we have published the article titled:

Succination is increased on select proteins in the brainstem of the Ndufs4 knockout mouse, a model of Leigh syndrome.” 

in the journal Molecular and Cellular Proteomics.

In this paper, we have been able to identify that the metabolic deficits mediated by mitochondrial dysfunction (we used our Leigh Syndrome mice for this study) lead to permanent modifications in discrete proteins in affected neurons.

These modifications (called succination) have been shown to impair the activity of proteins in other studies, therefore we believe these mitochondrial proteins will also lose function in our model. Interestingly, our study shows that these modifications are only observed in cells residing in areas affected by the pathology, further enhancing the idea that they may mediate the selective damage observed in mitochondrial disease.

The main proteins observed to be altered, VDAC1 and VDAC2, are key factors controlling transport of ions and molecules inside the mitochondria, so these results open a new and interesting line of research in the lab in the overarching goal of finding a cure for mito disease.