We will receive an ERC Proof of Concept Grant!

The European Research Council (ERC) has selected us for a Proof of Concept grant to develop a new research line focused on a novel approach to figh antibiotic resistances: the ResisTEST. This project, derived from the knowledge and experience gathered with NEUROMITO, has been chosen for its innovation potential, its significant impact and its quality, and will receive an amount of 150,000€ for a 18 month period. The objective is to bring closer to the market a new tool to help face one of the most important challenges that society will have to face within the next years: the antibiotic crisis. We are very glad to have this opportunity!

 

Research: Altered protein modifications in mitochondrial disease

Our latest paper is out!

In collaboration with the Frizzell lab at the University of South Carolina we have published the article titled:

Succination is increased on select proteins in the brainstem of the Ndufs4 knockout mouse, a model of Leigh syndrome.” 

in the journal Molecular and Cellular Proteomics.

In this paper, we have been able to identify that the metabolic deficits mediated by mitochondrial dysfunction (we used our Leigh Syndrome mice for this study) lead to permanent modifications in discrete proteins in affected neurons.

These modifications (called succination) have been shown to impair the activity of proteins in other studies, therefore we believe these mitochondrial proteins will also lose function in our model. Interestingly, our study shows that these modifications are only observed in cells residing in areas affected by the pathology, further enhancing the idea that they may mediate the selective damage observed in mitochondrial disease.

The main proteins observed to be altered, VDAC1 and VDAC2, are key factors controlling transport of ions and molecules inside the mitochondria, so these results open a new and interesting line of research in the lab in the overarching goal of finding a cure for mito disease.

 

 

 

The Quintana lab goes across the pond…

It has been an eventful couple of months for the Quintana lab.

It all started when we received a great offer to locate the lab at the Institute of Neurosciences at the Universitat Autonoma de Barcelona, in the outskirts of Barcelona, Spain and have our research funded by one of the prestigious ERC Starting Grants (NEUROMITO: more in current projects).

ercAfter some careful thought, we have decided that this is a great opportunity for the lab to grow and to pursue our goal of finding a cure for mitochondrial disease. This funding has allowed most of the lab to move to Barcelona and will sustain and enhance our research capability in the future.

Even though it is sad to leave Seattle and to say goodbye to our friends at Seattle Children’s Research Institute and the Northwest Mitochondrial Research Guild, we believe that this will be a positive move and that undoubtedly we will continue collaborating towards our common goal. We will always be in debt for the great opportunity, training and mentoring provided by our experience and colleagues in Seattle and we will continue to grow in Barcelona.

All “travelling” members: me (Albert), Eli, Alex, Irene and Kelsey are really looking forward to set our experiments up in Barcelona and we promise new and exciting updates soon! We are sad to leave Jessica and Ben behind, but we are sure they will have a bright and promising career in the future!

So, after a few years… we have to say: farewell Seattle and Welcome Barcelona!

 

 

Capcalera